Harvard Medical School
Department of Neurobiology
Congratulations to Ben, Brian, and former postdocs (Alex, Baptiste, and Ayal) for our latest paper published by Neuron on a key mechanism that explains how the suppression of transcytosis occures in the CNS to maintein the integrity of the blood-brain barrier!
Congratulations to Brian for our latest paper published by Neuron on the relative roles of tight junctions and transcytosis during the normal development of the functional blood-retinal barrier!
Lab lunch cerebration of Brian's paper at Fago de Chao!
A new student, Isle Bastille, just joined the lab! Welcome Isle!
A new postdoc, Urs Langen, just started his first day in the lab! Welcome Urs!
Congratulations to Sarah for receiving a Damon Runyon Fellowship Award!!!
Congratulations to Chenghua for being selected as a HHMI Faculty Scholar!!!!
here is the news: Philanthropies Announce Selection of Faculty Scholars
Goodbye Aleks and Erik, you will be missed! Thanks for the wonderful football trophy and the live EcoSphere!
A new student, Xavier du Maine, just joined the lab! Welcome Xavier!
Welcome to the spring in Boston! Amazing blooming in Chenghua's office:-)
Congratulations to Natasha for receiving a Damon Runyon Fellowship Award!!!
A new postdoc, Swathi Ayloo, just started her first day in the lab! Welcome Swathi!
A new postdoc, Sarah Pfau, just started her first day in the lab! Welcome Sarah!
Congratulations to Esther, Jiha, and Aleks for our latest paper published by elife on a general principle of how the vast diversity of densities of vascular networks is generated!
Celebrate chinese new year! In boston common after an amazing feast:-)
Science News about our work!
First day of imaging with our two-photon microscope!
The fantastic Gu Lab Halloween Beer Hour!
A new postdoc, Natasha O'Brown, just started her first day in the lab! Welcome Natasha!
Congratulations Baptiste for your new faculty position! We will miss you this spring when you leave!
Congratulations to Brian and Baptiste for our Review articles on the blood brain barrier and Neuro-vascular plasticity!
A new postdoc, Shachar Dagan, just started his first day in the lab! Welcome Shachar!
Check out our new microscope room! Air table just arrived and we can not wait to start building our very first 2-photon microscope!
A new postdoc, Vicente Nunez, just started his first day in the lab! Welcome Vicente!
The blood-brain barrier work in the news:
Congratulations to Ben and Baptiste for our Review article on Neuronal and Vascular Interactions in Annual Review of Neurosci !
The first Gu/Harvey/Sabatini lab ping pong tournament at Blazing Paddles!
The first cold spring harbor blood-brain barrier meeting football game!
The fantastic Gu Lab Halloween Beer Hour!
Our blood-brain barrier pumpkin! Did you guess that?!
Congratulations to Chenghua for your NIH Director's Pioneer Award!!!!
here is our spontaneous celebration!
Congratulations to Masha, Nellwyn,Aleks,Baptiste, and Won-Jongfor our latest paper published by elife on the function of neuropilin1 in angiogenesis!
Congratulations to Ben for your NIH NRSA fellowship award!!!!
Congratulations to Baptiste and Ayal for our latest paper published by Neuron on the relationship between neural activity and vascular network!
Welcome Brian to join the lab!
Team building in Vermont this weekend! Ben and Brian on the tandem bike!
Congratulations to Ayal, Baptiste, Esther, and Ben for our recent paper published by Nature on the formation and function of the blood-brain barrier!
Congratulations to Aleks for our recent paper published by J. of Cell Biology on semaphorin signaling!
5/12/2014 lab lunch celebration of our two recent papers!
A new postdoc, Jieqing Fan, just started her first day in the lab! Welcome Jieqing!
Congratulations Ayal for your new faculty position! We will miss you this fall when you leave!
Chenghua's interview by graduate students and postdocs at Stanford University
"Neurotalk" podcast at Stanford UniversityNeuroTalk S2E15 ChenghuaGu
Congratulations Chenghua for being promoted to an Associate Professor, and thanks to the past and current Gu lab members for your hard work!
Congratulations Won-Jong for your new faculty position! We will miss you!
Check out our latest paper, published today in the journal Neuron, Congratulations Won-Jong!
This paper demonstrates that neurovascular congruency in complex tissue does not follow the previous “one patterns the other” model in which either nerves or vessels instruct the other, but rather is established via a novel mechanism in which nerves and vessels are patterned independently.
lunch celebration of Won-Jong's Neuron paper
Welcome on board to Ben Andreone, a new student joined the lab!
Check out our new lab space !!!
We also look forward to many interactions with our new neighbors (labs of Pascal, Chris, and Bob)
Lab photo day!
Welcome on board to Baptiste Lacoste, a new postdoc in the lab!
Lab annual BBQ party at Chenghua's house
Welcome on board to Esther Kur, a new postdoc in the lab!
Congratulations to Masha, now Dr. Gelfand, for a successful Ph.D. thesis defense!
Happy New Year!
A new postdoc, Aleksandra Tata, just started her first day in the lab. Welcome Aleks!
Check out our latest paper, published today in the journal Nature Neuroscience!
This paper describes a novel function of Sema3E-Plexin-D1 signaling in determining synapse specificity in the basal ganglia system. It represents a fruitful collaboration between our lab and Bernardo Sabatini's lab in our department. The combined complementary approaches (electrophysiology, imaging, mouse genetics, optogenetics, in situ cytochemistry, and behavior analysis) allowed us to elucidate the function of Sema3E-Plexin-D1 signaling in the formation of cortico-thalamo-striatal circuits in vivo.
A new postdoc, Nellwyn Hagan, just started her first day in the lab! Welcome Nellwyn!
Check out our latest paper, published today in the journal Genes & Development, and it's the cover too!
This paper describes a novel molecular signaling cascade that regulates angiogenesis via a reciprocal interaction between VEGF and the traditional axon guidance ligand-receptor pair Semaphorin 3E-Plexin-D1.
This paper represents the collaborative efforts of Jiha and Won-Jong,and the team efforts of the whole Gu Lab. Congratulations to all!
Sema3E–Plexin-D1 signaling regulates angiogenic sprouting. Shown here is a wild-type, whole-mo B4 to label blood vessels (red), after in situ hybridization to identify mRNA (blue). The restricted Sema3E–Plexin-D1 signaling to be spatiotemporally regulated, which then modulates VEGF-mediated angi Dll4–Notch pathway. (For details, see Kim et al., p1399)
Copyright 2011 by the President and Fellows of Harvard College