4/13/2017

Congratulations to Ben, Brian, and former postdocs (Alex, Baptiste, and Ayal) for our latest paper published by Neuron on a key mechanism that explains how the suppression of transcytosis occures in the CNS to maintein the integrity of the blood-brain barrier!

 • Blood-brain barrier permeability is regulated by lipid transport-dependent suppression of caveolae-mediated transcytosis

News about this work: "Unlocking the barrier"

3/22/2017

Congratulations to Brian for our latest paper published by Neuron on the relative roles of tight junctions and transcytosis during the normal development of the functional blood-retinal barrier!

  •Gradual Suppression of Transcytosis Governs Functional Blood-Retinal Barrier Formation.

Lab lunch cerebration of Brian's paper at Fago de Chao!

3/6/2017

A new student, Isle Bastille, just joined the lab! Welcome Isle!

1/11/2017

A new postdoc, Urs Langen, just started his first day in the lab! Welcome Urs!

11/16/2016

Congratulations to Sarah for receiving a Damon Runyon Fellowship Award!!!

 

9/22/2016

Congratulations to Chenghua for being selected as a HHMI Faculty Scholar!!!!

here is the news: Philanthropies Announce Selection of Faculty Scholars

FacultyScholars2016-gallery

 

8/12/2016

Goodbye Aleks and Erik, you will be missed! Thanks for the wonderful football trophy and the live EcoSphere!

 

7/25/2016

A new student, Xavier du Maine, just joined the lab! Welcome Xavier!

 

5/17/2016

Welcome to the spring in Boston! Amazing blooming in Chenghua's office:-)

5/6/2016

Congratulations to Natasha for receiving a Damon Runyon Fellowship Award!!!

5/2/2016

A new postdoc, Swathi Ayloo, just started her first day in the lab! Welcome Swathi!

3/2/2016

A new postdoc, Sarah Pfau, just started her first day in the lab! Welcome Sarah!

2/24/2016

Congratulations to Esther, Jiha, and Aleks for our latest paper published by elife on a general principle of how the vast diversity of densities of vascular networks is generated!

  •Temporal modulation of collective cell behavior controls vascular network topology.

 

2/19/2016

Celebrate chinese new year! In boston common after an amazing feast:-)

 

1/24/2016

Science News about our work!

Blood exerts a powerful influence on the brain

1/22/2016

First day of imaging with our two-photon microscope!

 

10/31/2015

The fantastic Gu Lab Halloween Beer Hour!

10/15/2015

A new postdoc, Natasha O'Brown, just started her first day in the lab! Welcome Natasha!

11/10/2015

Congratulations Baptiste for your new faculty position! We will miss you this spring when you leave!

10/6/2015

Congratulations to Brian and Baptiste for our Review articles on the blood brain barrier and Neuro-vascular plasticity!

Chow and Gu (2015) Trends in Neurosci

Lacoste and Gu (2015) Mech Dev

9/5/2015

A new postdoc, Shachar Dagan, just started his first day in the lab! Welcome Shachar!

8/20/2015

Check out our new microscope room! Air table just arrived and we can not wait to start building our very first 2-photon microscope! 

4/1/2015

A new postdoc, Vicente Nunez, just started his first day in the lab! Welcome Vicente!

4/1/2015

The blood-brain barrier work in the news:

 

3/30/2015

Congratulations to Ben and Baptiste for our Review article on Neuronal and Vascular Interactions in Annual Review of Neurosci !

Andreone, Lacoste, and Gu (2015) Annu Rev Neurosci

 

3/24/2015

The first Gu/Harvey/Sabatini lab ping pong tournament at Blazing Paddles!

12/13/2014

The first cold spring harbor blood-brain barrier meeting football game!

10/31/2014

The fantastic Gu Lab Halloween Beer Hour!

                                                Our blood-brain barrier pumpkin! Did you guess that?!

 

9/23/2014

Congratulations to Chenghua for your NIH Director's Pioneer Award!!!!

here is our spontaneous celebration!

9/22/2014

Congratulations to Masha, Nellwyn,Aleks,Baptiste, and Won-Jongfor our latest paper published by elife on the function of neuropilin1 in angiogenesis!

  •Neuropilin-1 functions as a VEGFR2 co-receptor to guide developmental angiogenesis independent of ligand binding.

9/8/2014

Congratulations to Ben for your NIH NRSA fellowship award!!!!

8/21/2014

Congratulations to Baptiste and Ayal for our latest paper published by Neuron on the relationship between neural activity and vascular network!

 Lacoste et. al. Neuron, 2014

News report on this study.

Video abstract

Youtube video abstract

6/9/2014

Welcome Brian to join the lab!

 

6/7/2014

Team building in Vermont this weekend! Ben and Brian on the tandem bike!

5/26/2014

Congratulations to Ayal, Baptiste, Esther, and Ben for our recent paper published by Nature on the formation and function of the blood-brain barrier!

Ben-Zvi et. al. Nature (2014)

      

        News & Views in Nature 509(7501):432-3.

       Preview in Neuron 82(4):728-30.

       News report on this study.

 

5/26/2014

Congratulations to Aleks for our recent paper published by J. of Cell Biology on semaphorin signaling!

      Tata et.al. J. of Cell Biology, 2014.

      Podcast-biobytes May 26, 2014

5/12/2014 lab lunch celebration of our two recent papers!

5/1/2014

A new postdoc, Jieqing Fan, just started her first day in the lab! Welcome Jieqing!

4/1/2014

Congratulations Ayal for your new faculty position! We will miss you this fall when you leave!

3/12/2014

Chenghua's interview by graduate students and postdocs at Stanford University

"Neurotalk" podcast at Stanford UniversityNeuroTalk S2E15 ChenghuaGu

or weblink:chenghua

1/13/2014

Congratulations Chenghua for being promoted to an Associate Professor, and thanks to the past and current Gu lab members for your hard work!

12/15/2013

Congratulations Won-Jong for your new faculty position! We will miss you!

10/18/2013

Check out our latest paper, published today in the journal Neuron, Congratulations Won-Jong!

Establishment of neurovascular congruency in the mouse whisker system by an independent patterning mechanism

This paper demonstrates that neurovascular congruency in complex tissue does not follow the previous “one patterns the other” model in which either nerves or vessels instruct the other, but rather is established via a novel mechanism in which nerves and vessels are patterned independently.

Preview in neuron

News resport

lunch celebration of Won-Jong's Neuron paper

 

8/1/2013

Welcome on board to Ben Andreone, a new student joined the lab!

3/6/2013

Check out our new lab space !!!

We also look forward to many interactions with our new neighbors (labs of Pascal, Chris, and Bob)

         

           

    

                

 

 

9/28/2012

Lab photo day!

9/1/2012

Welcome on board to Baptiste Lacoste, a new postdoc in the lab!

7/22/2012

Lab annual BBQ party at Chenghua's house

 

6/1/2012

Welcome on board to Esther Kur, a new postdoc in the lab!

 

4/15/2012

Congratulations to Masha, now Dr. Gelfand, for a successful Ph.D. thesis defense!

1/1/2012

Happy New Year!

A new postdoc, Aleksandra Tata, just started her first day in the lab. Welcome Aleks!

12/18/2011

Check out our latest paper, published today in the journal Nature Neuroscience!

Semaphorin3E-Plexin-D1 signaling controls pathway-specific synapse formation in the striatum

This paper describes a novel function of Sema3E-Plexin-D1 signaling in determining synapse specificity in the basal ganglia system. It represents a fruitful collaboration between our lab and Bernardo Sabatini's lab in our department. The combined complementary approaches (electrophysiology, imaging, mouse genetics, optogenetics, in situ cytochemistry, and behavior analysis) allowed us to elucidate the function of Sema3E-Plexin-D1 signaling in the formation of cortico-thalamo-striatal circuits in vivo.

11/1/2011

A new postdoc, Nellwyn Hagan, just started her first day in the lab! Welcome Nellwyn!

7/1/2011

Check out our latest paper, published today in the journal Genes & Development, and it's the cover too!

Semaphorin 3E–Plexin-D1 signaling regulates VEGF function in developmental angiogenesis via a feedback mechanism

This paper describes a novel molecular signaling cascade that regulates angiogenesis via a reciprocal interaction between VEGF and the traditional axon guidance ligand-receptor pair Semaphorin 3E-Plexin-D1.

This paper represents the collaborative efforts of Jiha and Won-Jong,and the team efforts of the whole Gu Lab. Congratulations to all!

 

Sema3E–Plexin-D1 signaling regulates angiogenic sprouting. Shown here is a wild-type, whole-mo B4 to label blood vessels (red), after in situ hybridization to identify mRNA (blue). The restricted Sema3E–Plexin-D1 signaling to be spatiotemporally regulated, which then modulates VEGF-mediated angi Dll4–Notch pathway. (For details, see Kim et al., p1399)

Lunch celebration!

lab photos