Selected publications from the laboratory:

 

 • Andrenoe, B.J., Chow, B.W., Tata, A., Lacoste, B., Ben-Zvi, A., Bullock, K., Deik, A.A., Ginty, D.D., Clish, C.B., Gu C., (2017) Blood-brain barrier permeability is regulated by lipid transport-dependent suppression of caveolae-mediated transcytosis Neuron, 94(3) 581-594. NIHMS 865093

        News report on this study-"Unlocking the Barrier"

  •Chow,B.C, Gu C., (2017) Gradual Suppression of Transcytosis Governs Functional Blood-Retinal Barrier Formation. Neuron, 93(6)1325-1333

        News report on this study.

        "Filtering more than light in the developing retina"-commentary in Science Translational Medicine.

       

  •Kur, E., Kim, J., Tata, A., Comin, C.H., Harrington, K.I., Costa, L.,, Bentley. K., Gu C., (2016) Temporal modulation of collective cell behavior controls vascular network topology. Elife. 2016 Feb 24; [Epub ahead of print]

 •Chow.B.W., Gu, C., (2015) The molecular constituents of the blood-brain barrier. Trends Neurosci.38(10):598-608

 •Lacoste, B., Gu, C., (2015) Control of cerebrovascular patterning by neural activity during postnatal development. Mech Dev. 138 Pt 1:43-9. PMC4166422

 •Andreone, B.J., Lacoste, B., Gu, C., (2015) Neuronal and vascular interactions. Annu Rev Neurosci.38:25-46.

 • Keskin, D., Kim, J., Cooke, V.G., Wu, C.C., Sugimoto, H., Gu C, De Palma, M., Kalluri, R., LeBleu, V.S., (2015) Targeting vascular pericyte in hypoxic tumors increases lung metastasis via angiopoietin-2. Cell Rep. 10(7):1066-81.

 • Almasi S, Xu X, Ben-Zvi A, Lacoste B, Gu C., Miller EL., (2015) A novel method for identifying a graph-based representation of 3-D microvascular networks from fluorescence microscopy image stacks. Med Image Anal, 20 (1):208-23.

  •Gelfand, M.V., Hagan, N., Tata, A., Oh, W.J., Lacoste, B., Kang, K.T., Kopycinska, J., Bischoff, J., Wang, J.H., Gu C., (2014) Neuropilin-1 functions as a VEGFR2 co-receptor to guide developmental angiogenesis independent of ligand binding. Elife. 2014 Sep 22;3. doi: 10.7554/eLife.03720. [Epub ahead of print]

 

  • Lacoste, B., Comin, C.H., Ben-Zvi, A., Kaeser, P.S., Xu, X., Costa, L., and Gu, C., (2014) Sensory-related neural activity regulates the structure of vascular networks in the cerebral cortex. Neuron, 83(5):1117-30.

        News report on this study.

        Video abstract

        Science News on this study

 

Ben-Zvi, A., Lacoste, B., Kur, E., Andreone, B.J., Mayshar, Y., Yan, H., Gu, C., (2014) MFSD2A is critical for the formation and function of the blood brain barrier.  Nature, 509(7501):507-11.

      

       News & Views in Nature 509(7501):432-3.

       Preview in Neuron 82(4):728-30.

       News report on this study.

Tata, A., Stoppel, D., Hong, S., Ben-Zvi, A., Xie, T., Gu, C., (2014) An image-based RNAi screen identifies SH3BP1 as a key effector of Semaphoring 3E-PlexinD1 signaling. J Cell Biol, 205(4):573-590.

     

      Podcast-biobytes May 26, 2014

  Straub, C., Tritsch, NX, Hagan NA, Gu, C., Sabatini, B., (2014) Multiphasic modulation of cholinergic interneurons by nigrostriatal afferents. J Neuroscience,34(25):8557-69

 

Tritsch, N., Oh, W., Gu, C., Sabatini, B., (2014) Midbrain dopamine neurons sustain inhibitory transmission using plasma membrane uptake of GABA, not synthesis. elife,2014 Apr 24;3:e01936. doi: 10.7554/eLife.01936.

  • Oh, W., Gu, C., (2013) Establishment of neurovascular congruency in the mouse whisker system by an independent patterning mechanism. Neuron. 80(2):458-469.

         Supplementary Marterials

       Preview in Neuron

       Also see news report on the study.

  Gu, C., Giraudo E.,  (2013) The role of semaphorins and their receptors in vascular development and cancer.  Exp Cell Res. 2013 Feb 17. pii: S0014-4827(13)00046-3. doi: 10.1016/j.yexcr.2013.02.003. [Epub ahead of print]

  • Oh, W., Gu, C., (2012) The role and mechanism-of-action of Sema3E and Plexin-D1 in vascular and neural development. Seminars in Cell and Developmental Biology. 2012 Dec 25. pii: S1084-9521(12)00217-0. doi: 10.1016/j.semcdb.2012.12.001. [Epub ahead of print]. PMID:23270617.

  • Kwon, H., Kozorovitskiy, Y., Oh, W., Peixoto, R., Akhtar, N., Saulnier, J. L., Gu, C., Sabatini, B.L., (2012) Cortical synaptogenesis and excitatory synapse number are determined via a Neuroligin-1-dependent intercellular competition. Nature Neuroscience. 2012 Nov;15(12):1667-74. doi: 10.1038/nn.3256. PMC3536444

         Supplementary Marterials

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• Ding*, J., Oh*, W., Sabatini, B.L., Gu, C., (2011) Semaphorin3E-Plexin-D1 signaling controls pathway-specific synapse formation in the striatum. Nature Neuroscience. 2011 Dec 18. doi: 10.1038/nn.3003. [Epub ahead of print].

        Supplementary Marterials

• Kim*, J., Oh*, W., Gaiano, N., Yoshida, Y., Gu, C., (2011) Semaphorin 3E-Plexin-D1 signaling regulates VEGF function in developmental angiogenesis via a feedback mechanism.Genes & Development. 25 (13):1399-411.
Selected to be the cover.
Also see news report on the study.

       News and views in Dev Cell

• De Almodovar,C.,Fabre, P., Knevels, E., Coulon,C., Segura, I., Haddick, P., Aerts, L., Delattin, N., Strasser, G., Oh, W., Lange, C., Vinckier, S.,  Haigh, J., Fouquet,C., Henderson, C.,  Gu, C., Alitalo, K., Castellani, V., Tessier-Lavigne, M., Chedotal, A Charron, F., Carmeliet, P., (2011) VEGF mediates commissural axon chemoattraction through its receptor Flk1. Neuron. 70(5):966-78.

• Piper, M., Plachez, C., Zalucki,O., Fothergill, T., Goudreau, G., Erzurumlu, R., Gu, C., Richards LJ., (2009) Neuropilin 1-Sema Signaling Regulates Crossing of Cingulate Pioneering Axons during Development of the Corpus Callosum. Cereb Cortex. Suppl 1:i11-21.

• Gelfand, M. V., Hong, S., Gu, C., (2009) Guidance from above: common cues direct distinct signaling outcomes in vascular and neural patterning. Trends in Cell Biology. 19(3):99-110.

• Huber, A. B., Kania, A., Tran, T.S., Gu, C., De Marco, N., Lieberam, I., Johnson, D.,Jessell, T.M., Ginty, D.D., Kolodkin, A.L., (2005) Distinct roles for secreted semaphorin signaling in spinal motor axon guidance. Neuron. 48(6): 949-64.

• Gammill, L.S., Gonzalez, C., Gu, C., Bronner-Fraser, M., (2005) Guidance of trunk neural crest migration requires Neuropilin-2/Semaphorin3F signaling. Development. 133(1):99-106.

• Mukouyama, Y., Gerber, H., Ferrara, N., Gu, C., Anderson, D.J., (2005) Peripheral nerve-derived VEGF  promotes  arteriogenesis via Neuropilin-1-mediated positive-feedback.   Development>. 132(5):941-952.

Gu, C., Yoshida, Y., Livet, J.,Reimert, D.V., Mann, F., Merte, J., Henderson, C.E., Jessell, T.M., Kolodkin, A.L., Ginty, D.D. (2005) Semaphorin3E and Plexin-D1 control vascular pattern independently of Neuropilins. Science. 307 (5707):265-268. Supplementary Materials

• Schwarz, Q., Gu, C., Fujisawa , H., Sabelko, K., Golding, M., Cheng, H., Marina Gertsenstein, M., Nagy, A., Taniguchi, M., Kolodkin, A.L., Ginty, D.D., Shima, D.T., Ruhrberg, C. (2004) Vascular endothelial growth factor cooperates with Sema3A to pattern different compartments of the facial nerve. Genes & Development. 18 (22): 2822-2834. Supplementary Materials: Fig. 1, Fig. 2, Legends.

Gu, C., Rodriguez, E.R., Reimert, D.V., Shu, T., Fritzsch, B., Richards, L.J., Kolodkin, A.L., Ginty, D.D. (2003) Neuropilin-1 conveys Semaphorin and VEGF signaling during neural and cardiovascular development.Developmental Cell. 5 (1):45-57.

Gu, C., Limberg, B.J., Whitaker, G.B., Perman, B., Leahy, D.J., Rosenbaum, J.S., Ginty, D.D., Kolodkin, A.L. (2002) Characterization of neuropilin-1 structural features that confer binding to semaphorin 3A and vascular endothelial growth factor 165. J Biol Chem. 17; 277(20):18069-76.

Gu, C., Ma, Y., Benjamin, J., Littman, D., Chao, M.V., and Huang, X. (2000) Apoptotic signaling through the -adrenergic receptor: A new Gs coupled mechanism. J. Biol Chem. 275(27):20726-33.

Gu, C., Casaccia-Bonnefil, P., Srinivasan, A., and Chao, M.V.(1999) Oligodendrocyte apoptosis mediated by caspase activation. J. Neurosci. 19(8):3043-3049.

• Casaccia-Bonnefil, P., Gu, C., Khursigara, G., and Chao, M.V. (1999) The p75 neurotrophin receptor as a modulator of survival and death decisions. Microsc Res Tech. 45(4-5):217-24.

• Casaccia-Bonnefil, P., Gu, C., and Chao, M.V. (1999) Neurotrophins in cell survival/death decisions. Adv Exp Med Biol. 468:275-82.

Gu, C., Castellino, A., Chan, J., and Chao, M.V. (1998) BRE: A modulator of TNF-alpha action. FASEB J. 12:1101-1108.